abstract：:HLA-DR antigens were determined in 111 patients with classic or definite rheumatoid arthritis. HLA-DR4 was significantly (P corr. less than 10(-6] increased in patients with rheumatoid arthritis (54%) compared with controls (23.2%). HLA-DR 5 was decreased in rheumatoid arthritis (12.6% vs 26.4% of controls); however, ...

journal_title：Rheumatology international

authors： Scherak O,Smolen JS,Mayr WR

更新日期：1983-01-01 00:00:00

abstract：:Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...

journal_title：Rheumatology international

authors： Burmester GR,Locher P,Koch B,Winchester RJ,Dimitriu-Bona A,Kalden JR,Mohr W

更新日期：1983-01-01 00:00:00

abstract：:A critical analysis has been performed of reports published on the incidence of gastro-intestinal (GI) side-effects found in arthritic patients being treated with non-steroid anti-inflammatory (NSAI) drugs. The results show the following: 1. The incidence of GI ulceration (as revealed by gastroscopy) and haemorrhage i...

journal_title：Rheumatology international

authors： Rainsford KD

更新日期：1982-01-01 00:00:00

abstract：:The synovial fluids (SF) of patients with rheumatoid arthritis (RA) were investigated for their effects on thymocytes of C3H/HeJ mice. Of the 20 SF tested, 17 (85%) showed an augmentation of the phytohaemagglutinin (PHA) induced thymocyte stimulation. Out of 16 SF of patients with osteoarthrosis, such an activity was ...

journal_title：Rheumatology international

authors： Fontana A,Hengartner H,Weber E,Fehr K,Grob PJ,Cohen G

更新日期：1982-01-01 00:00:00

abstract：:Analyses of the synovial tissue and fluid T lymphocytes obtained from patients with rheumatoid arthritis revealed multiple functional defects in the regulation of autologous blood B cell differentiation into cells secreting immunoglobulin. These abnormalities were not found in peripheral blood T lymphocytes from the s...

journal_title：Rheumatology international

authors： Romain PL,Burmester GR,Enlow RW,Winchester RJ

更新日期：1982-01-01 00:00:00

abstract：:The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease seve...

journal_title：Rheumatology international

authors： Banford JC,Brown DH,Hazelton RA,McNeil CJ,Smith WE,Sturrock RD

更新日期：1982-01-01 00:00:00

abstract：:Necrotic areas of rheumatoid nodules were investigated electron microscopically. PMNs in different stages of disintegration were present in all cases. Granular material, sometimes in a fiberlike orientation, and small fibrils without periodicity were detected between the collagenous fibers. It is assumed that granular...

journal_title：Rheumatology international

authors： Mohr W,Köhler G,Wessinghage D

更新日期：1981-01-01 00:00:00

abstract：:The American Rheumatism Association (ARA) clinical criteria have been tested in systemic lupus erythematosus (SLE), progressive systemic sclerosis, polyarteritis nodosa and polymyositis/dermatomyositis. Hospital admissions from a defined population over the same period were studied. Increased weighting of the scores f...

journal_title：Rheumatology international

authors： Tan PL,Borman GB,Wigley RD

更新日期：1981-01-01 00:00:00

abstract：:Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodi...

journal_title：Rheumatology international

authors： Chitrabamrung S,Rubin RL,Tan EM

更新日期：1981-01-01 00:00:00

abstract：:We have prepared antibody/3H-dsDNA immune complexes and have used three independent radioimmunoassays to quantitate their interaction with complement; the solution phase C1q assay, the Raji cell assay, and a complement-based red blood cell adherence assay (RBC-CF). Our results indicate that although there is reasonabl...

journal_title：Rheumatology international

authors： Taylor RP,Andrews BS,Morley KW,Conlon T

更新日期：1981-01-01 00:00:00